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Metronidazole should be used with caution in patients with active or chronic severe peripheral and central nervous system diseases due to the risk of neurological aggravation. Antibiotics in treating abscesses in the liver, pelvis, abdomen and brain caused by susceptible anaerobic bacteria, amebiasis, trichomoniasis and asymptomatic partners of infected patients. Minor side effects are appetite loss, drowsiness, diarrhea, metallic taste, headaches, stomach upset and vomiting. Flagyl or Metronidazole is the effective modern antibiotic. Metronidazole should be stored at room temperature and protected from light. It is not necessary to take this drug with food, unless an upset stomach occurs. Stopping the medication too early may allow bacteria to continue to grow resulting in a relapse of the infection. When administered systemically via oral tablets, Metronidazole works by inhibiting bacterial DNA synthesis hence preventing the replication of bacteria. Metronidazole is usually taken two or three times a day for ten days or longer.