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Be safe and effective for the treatment of many bacterial infections. Side effects of Levaquin include tendon ruptures and other tendon type of injuries. Given with theophylline, Levofloxacin can increase theophylline blood levels. Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Levaquin was initially an extremely successful product both in terms of the revenue it produced and the percentage of success it enjoyed with patients. Levaquin is known as Levaquin. Levaquin can make your skin sensitive to the sun photosensitivity and the light from sunlamps and tanning beds. Taking Levofloxacin with an acidic beverage such as a cola drink may increase its absorption.